- Mcr-1 gene seen in K. pneumoniae bacteria
- mobilized colistin resistance (mcr-1) gene that confers multidrug-resistance has now been reported in Klebsiella pneumoniae bacteria
- This gene endows resistance against last hope antibiotic — colistin
- The mcr-1 gene is usually found in the plasmid (small DNA in the cytoplasm)
- Colistin, also known as polymyxin E, is an antibiotic produced by certain strains of the bacteria Paenibacillus polymyxa.
- Colistin has also been used recently to treat ventilator-associated pneumonia (VAP) and bacteremia caused by MDR bacteria, such as P. aeruginosa, K. pneumoniae and A. baumannii.