- Parkinson’s disease is a chronic, degenerative neurological disorder that affects the central nervous system.
- It damages nerve cells in the brain dropping the levels of dopamine. Dopamine is a chemical that sends behavioral signals from the brain to the body.
- The disease causes a variety of “motor” symptoms (symptoms related to movement of the muscles), including rigidity, delayed movement, poor balance, and tremors.
- Medication can help control the symptoms of the disease but it can’t be cured.
- It affects the age group from 6 to 60 years.
- An aggregation of a protein called Alpha-synuclein (ASyn) plays a crucial role in the development of Parkinson’s disease.
- Protein aggregation is a biological phenomenon in which destabilized proteins aggregate (i.e., accumulate and clump together) leading to many diseases.
- Alpha-synuclein is a protein found in the human brain, while smaller amounts are found in the heart, muscle and other tissues.
- In the brain, alpha-synuclein is found mainly at the tips of neurons in specialized structures called presynaptic terminals.
- Presynaptic terminals release chemical messengers, called neurotransmitters.
- The release of neurotransmitters relays signals between neurons and is critical for normal brain function.
- Until now, worldwide studies could not establish any strong relation between ASyn aggregations and subsequent death of neuronal cells observed in Parkinson’s disease.
- Recently, scientists from IIT (Indian School of Mines) Dhanbad and CSIR-Indian Institute of Chemical Biology (Kolkata) have developed the Z-scan method to monitor the origin as well as the progression of Parkinson’s disease in human beings.
- The discovered Z-scan method is expected to help in monitoring both the early as well as late stages of the aggregation of ASyn and death of neuronal cells.
CSIR-Indian Institute of Chemical Biology
- Indian Institute of Chemical Biology (IICB) was established in 1935 as the first non-official center in India for biomedical research and was included within the aegis of Council of Scientific and Industrial Research (CSIR) in 1956.
- It is located in Kolkata (West Bengal).
- CSIR-IICB is engaged in research on diseases of national importance and biological problems of global interest and also helps to maintain momentum in life science research.
- It conducts research in a variety of areas including chemistry, biochemistry, cell biology, molecular biology, neurobiology and immunology which promotes productive interdisciplinary interaction.